ACTIDIONE AR |
| Synonyms : Cycloheximide, 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Naramycin A |
SECTION 1: Identification of the substance/mixture and of the company/undertaking |
|||
|---|---|---|---|
1.1 Product identifier |
|||
| Chemical Name : | Actidione 98% AR | ||
| Catalogue No. : | AL0113 | Product form : | Substance |
| CAS Number : | 66-81-9 | EC Number : | 200-636-0 |
| Grade : | EC Index Number : | 613-140-00-8 | |
| Chemical Formula : | C15H23NO4 | HSN Code : | 29419011 |
| Synonyms : | Cycloheximide / Naramycin A / 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2- hydroxyethyl]glutarimide | ||
| Chemical Structure : |
|
||
1.2 Relevant identified uses of the substance or mixture and uses advised against |
|||
| Use of the substance/mixture : | Laboratory chemicals, Manufacture of substances | ||
| Uses advised against : | No additional information available | ||
1.3 Details of the supplier of the safety data sheet |
|||
| Company identification : | Address:- 102, B wing, Savgan Heights, RTO Lane, Andheri (W), Mumbai-400 053 Maharashtra, India. |
||
1.4 Emergency Contact Details |
|||
| Phone / e-Mail : | Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in |
||
SECTION 2: Hazards identification |
|
|---|---|
2.1 Classification of the substance or mixture |
|
| Classification according to Regulation (EC) No. 1272/2008 [CLP] | |
|
Reproductive toxicity, Category 1B H360D Acute toxicity (oral), Category 1 H300 Germ cell mutagenicity, Category 2 H341 Hazardous to the aquatic environment Chronic Hazard, Category 2 H411 Full text of classification categories and H statements : see section 16 |
|
| Classification according to Directive 67/548/EEC or 1999/45/EC | |
| Muta.Cat.3; R68 Repr.Cat.2; R61 T+; R28 N; R51/53 Full text of R-phrases: see section 16 |
|
| Adverse physicochemical, human health and environmental effects | |
| No additional information available | |
2.2 Label elements |
|
| Labelling according to Regulation (EC) No. 1272/2008 [CLP] | |
| Hazard pictograms (CLP) : |
 GHS06
 GHS08
 GHS09
|
| Signal word (CLP) : | Danger |
| Hazard statements (CLP) : | H300 - Fatal if swallowed H341 - Suspected of causing genetic defects H360D - May damage the unborn child H411 - Toxic to aquatic life with long lasting effects |
| Precautionary statements (CLP) : | P201 - Obtain special instructions before use P264 - Wash hands thoroughly after handling P273 - Avoid release to the environment P301+P310 - IF SWALLOWED: Immediately call a doctor P308+P313 - IF exposed or concerned: Get medical advice/attention P280 - Wear protective gloves, protective clothing, eye protection, face protection |
2.3 Other hazards |
|
| Other hazards : | No additional information available |
SECTION 3: Composition/information on ingredients |
|||
|---|---|---|---|
3.1. Substance |
|||
| Name : | ACTIDIONE AR | ||
| CAS No. : | 66-81-9 | ||
| EC Index No. : | 613-140-00-8 | ||
| EC No. : | 200-636-0 | ||
| Full text of R- and H-phrases: see section 16 | |||
3.2. Mixture |
|||
| Not applicable | |||
SECTION 4: First aid measures |
|
|---|---|
4.1 Description of first aid measures |
|
| First-aid measures after inhalation : | Assure fresh air breathing. If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
| First-aid measures after skin contact : | Wash with plenty of soap and water. Get immediate medical advice/attention. |
| First-aid measures after eye contact : | Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Get medical advice/attention. |
| First-aid measures after ingestion : | Rinse mouth. Immediately call a POISON CENTER or doctor/physician. |
4.2 Most important symptoms and effects, both acute and delayed |
|
| Symptoms relating to use : | Symptoms/injuries : May damage the unborn child. Suspected of causing genetic defects. Symptoms/injuries after ingestion : Fatal if swallowed. |
4.3 Indication of any immediate medical attention and special treatment needed |
|
| General information : | Treat symptomatically. |
SECTION 5: Fire-fighting measures |
|
|---|---|
5.1 Extinguishing media |
|
| Suitable extinguishing media : | Carbon dioxide. Dry powder. Foam. Water spray. |
| Unsuitable extinguishing media : | Do not use extinguishing media containing water. |
5.2 Special hazards arising from the substance or mixture |
|
| Special procedures : | No additional information available |
5.3 Advice for firefighters |
|
| Protection during firefighting : | Do not enter fire area without proper protective equipment, including respiratory protection. |
SECTION 6: Accidental release measures |
|
|---|---|
6.1 Personal precautions, protective equipment and emergency procedures |
|
6.1.1. For non-emergency personnel |
|
| Emergency procedures : | Evacuate unnecessary personnel. |
6.1.2. For emergency responders |
|
| Protective equipment | Use personal protective equipment as required |
| Emergency procedures | Ventilate area. |
6.2 Environmental precautions |
|
| Toxic to aquatic life with long lasting effects. | |
6.3 Methods and material for containment and cleaning up |
|
| Methods for cleaning up : | On land, sweep or shovel into suitable containers. Soak up spills with inert solids, such as clay or diatomaceous earth as soon as possible. |
6.4 Reference to other sections |
|
| Reference : | No additional information available |
SECTION 7: Handling and storage |
|
|---|---|
7.1 Precautions for safe handling |
|
| Precautions for safe handling : | Obtain special instructions before use. Use personal protective equipment as required. Avoid contact with skin and eyes. Do not breathe vapours. Avoid dust formation. |
| Hygiene measures : | Do not eat, drink or smoke when using this product. Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work. |
7.2 Conditions for safe storage, including any incompatibilities |
|
| Storage conditions : | Store in a well-ventilated place. Keep container tightly closed. |
7.3 Specific end use(s) |
|
| No additional information available | |
SECTION 8: Exposure controls/personal protection |
|
|---|---|
8.1 Control parameters |
|
| No additional information available | |
8.2 Exposure controls |
|
| Hand protection : | Protective gloves |
| Eye protection : | Chemical goggles or safety glasses |
| Skin and body protection : | Wear suitable protective clothing |
| Respiratory protection : | Wear respiratory protection |
SECTION 9: Physical and chemical properties |
|
|---|---|
9.1 Information on basic physical and chemical properties |
|
| Physical state : | Solid |
| Molecular mass : | 281.35 g/mol |
| Colour : | White powder. |
| Odour : | odourless. |
| Odour threshold : | No data available |
| pH value : | No data available |
| Relative evaporation rate (butylacetate=1) : | No data available |
| Melting point : | 120 °C |
| Freezing point : | No data available |
| Boiling point : | No data available |
| Flash point : | No data available |
| Auto-ignition temperature : | No data available |
| Decomposition temperature : | No data available |
| Flammability (solid, gas) : | No data available |
| Vapour pressure : | No data available |
| Relative vapour density at 20°C : | No data available |
| Solubility : | Water: Slightly soluble |
| Log Pow : | 0.55 |
| Viscosity, kinematic : | No data available |
| Viscosity, dynamic : | No data available |
| Explosive properties : | No data available |
| Oxidising properties : | No data available |
| Explosive limits : | No data available |
9.2 Other information |
|
| No additional information available | |
SECTION 10: Stability and reactivity |
|
|---|---|
10.1 Reactivity |
|
| No additional information available | |
10.2 Chemical stability |
|
| Stable under normal conditions. | |
10.3 Possibility of hazardous reactions |
|
| No additional information available | |
10.4 Conditions to avoid |
|
| Air contact. Moisture. | |
10.5 Incompatible materials |
|
| No additional information available | |
10.6 Hazardous decomposition products |
|
| No additional information available |
SECTION 11: Toxicological information |
|
|---|---|
11.1 Information on toxicological effects |
|
| Acute toxicity : | Oral: Fatal if swallowed. |
| Skin corrosion/irritation : | Not classified |
| Serious eye damage/irritation : | Not classified |
| Respiratory or skin sensitisation : | Not classified |
| Germ cell mutagenicity : | Suspected of causing genetic defects. |
| Carcinogenicity : | Not classified |
| Reproductive toxicity : | May damage the unborn child. |
| Specific target organ toxicity (single exposure) : | Not classified |
| Specific target organ toxicity (repeated exposure) : | Not classified |
| Aspiration hazard : | Not classified |
| Potential adverse human health effects and symptoms : | Fatal if swallowed. |
SECTION 12: Ecological information |
|
|---|---|
12.1 Toxicity |
|
| Toxicity information : | Ecology - water : Toxic to aquatic life with long lasting effects. |
12.2 Persistence - degradability |
|
| Persistence - degradability : | Actidione 98% AR (66-81-9) Persistence and degradability May cause long-term adverse effects in the environment. |
12.3 Bioaccumulative potential |
|
| Bioaccumulative potential : | Actidione 98% AR (66-81-9) Log Pow 0.55 |
12.4 Mobility in soil |
|
| Mobility in soil : | No additional information available |
12.5 Results of PBT and vPvB assessment |
|
| No additional information available | |
12.6 Other adverse effects |
|
| Environmental precautions : | No additional information available |
SECTION 13: Disposal considerations |
|
|---|---|
13.1 Waste treatment methods |
|
| Product/Packaging disposal recommendations : | Dispose of contents/container to ... |
| Ecology - waste materials : | Hazardous waste due to toxicity. |
SECTION 14: Transport information |
|
|---|---|
| In accordance with ADR / RID / IMDG / IATA / ADN | |
14.1. UN number |
|
| UN-No. (ADR) : | 2811 |
| UN-No. (IMDG) : | 2811 |
| UN-No. (IATA) : | 2811 |
| UN-No. (ADN) : | 2811 |
| UN-No. (RID) : | 2811 |
14.2. UN proper shipping name |
|
| Proper Shipping Name (ADR) : | TOXIC SOLID, ORGANIC, N.O.S. |
| Proper Shipping Name (IMDG) : | TOXIC SOLID, ORGANIC, N.O.S. |
| Proper Shipping Name (IATA) : | TOXIC SOLID, ORGANIC, N.O.S. |
| Proper Shipping Name (ADN) : | TOXIC SOLID, ORGANIC, N.O.S. |
| Proper Shipping Name (RID) : | TOXIC SOLID, ORGANIC, N.O.S. |
| Transport document description (ADR) : | UN 2811, TOXIC SOLID, ORGANIC, N.O.S., 6.1, I ENVIRONMENTALLY HAZARDOUS |
| Transport document description (IMDG) : | UN 2811, TOXIC SOLID, ORGANIC, N.O.S., 6.1, I ENVIRONMENTALLY HAZARDOUS |
| Transport document description (IATA) : | UN 2811, TOXIC SOLID, ORGANIC, N.O.S., 6.1, I ENVIRONMENTALLY HAZARDOUS |
| Transport document description (ADN) : | UN 2811, TOXIC SOLID, ORGANIC, N.O.S., 6.1, I ENVIRONMENTALLY HAZARDOUS |
| Transport document description (RID) : | UN 2811, TOXIC SOLID, ORGANIC, N.O.S., 6.1, I ENVIRONMENTALLY HAZARDOUS |
14.3. Transport hazard class(es) |
|
| ADR | |
| Transport hazard class(es) : | 6.1 |
| Danger labels : | 6.1 
|
| IMDG | |
| Transport hazard class(es) : | 6.1 |
| Danger labels : | 6.1
|
| IATA | |
| Transport hazard class(es) : | 6.1 |
| Danger labels : | 6.1
|
| ADN | |
| Transport hazard class(es) : | 6.1 |
| Danger labels : | 6.1
|
| RID | |
| Transport hazard class(es) : | 6.1 |
| Danger labels : | 6.1
|
14.4. Packing group |
|
| Packing group (ADR) : | I |
| Packing group (IMDG) : | I |
| Packing group (IATA) : | I |
| Packing group (ADN) : | I |
| Packing group (RID) : | I |
14.5. Environmental hazards |
|
| Dangerous for the environment : | Yes |
| Marine pollutant : | Yes |
| Other information : | No supplementary information available |
14.6. Special precautions for user |
|
| - Overland transport | |
|
Classification code (ADR) : T2 Special provision (ADR) : 274, 614 Limited quantities (ADR) : 0 Excepted quantities (ADR) : E5 Packing instructions (ADR) : P002, IBC07 Mixed packing provisions (ADR) : MP18 Portable tank and bulk container instructions (ADR) : T6 Portable tank and bulk container special provisions (ADR) : TP33 Tank code (ADR) : S10AH, L10CH Tank special provisions (ADR) : TU15, TE19 Vehicle for tank carriage : AT Transport category (ADR) : 1 Special provisions for carriage - Packages (ADR) : V10 Special provisions for carriage - Loading, unloading and handling (ADR) : CV1, CV13, CV28 Special provisions for carriage - Operation (ADR) : S9, S14 Hazard identification number (Kemler No.) : 66 Orange plates : Tunnel restriction code (ADR) : C/E EAC code : 2X |
|
| - Transport by sea | |
|
Special provision (IMDG) : 274 Limited quantities (IMDG) : 0 Excepted quantities (IMDG) : E5 Packing instructions (IMDG) : P002 IBC packing instructions (IMDG) : IBC99 Tank instructions (IMDG) : T6 Tank special provisions (IMDG) : TP33 EmS-No. (Fire) : F-A EmS-No. (Spillage) : S-A Stowage category (IMDG) : B MFAG-No : 151 |
|
| - Air transport | |
|
PCA Excepted quantities (IATA) : E5 PCA Limited quantities (IATA) : Forbidden PCA limited quantity max net quantity (IATA) : Forbidden PCA packing instructions (IATA) : 666 PCA max net quantity (IATA) : 5kg CAO packing instructions (IATA) : 673 CAO max net quantity (IATA) : 50kg Special provision (IATA) : A3, A5 ERG code (IATA) : 6L |
|
| - Inland waterway transport | |
|
Classification code (ADN) : T2 Special provisions (ADN) : 274, 614, 802 Limited quantities (ADN) : 0 Excepted quantities (ADN) : E5 Equipment required (ADN) : PP, EP Number of blue cones/lights (ADN) : 2 |
|
| - Rail transport | |
|
Classification code (RID) : T2 Special provision (RID) : 274, 614 Limited quantities (RID) : 0 Excepted quantities (RID) : E5 Packing instructions (RID) : P002, IBC07 Mixed packing provisions (RID) : MP18 Portable tank and bulk container instructions (RID) : T6 Portable tank and bulk container special provisions (RID) : TP33 Tank codes for RID tanks (RID) : S10AH, L10CH Special provisions for RID tanks (RID) : TU15, TU38, TE22 Transport category (RID) : 1 Special provisions for carriage – Packages (RID) : W10 Special provisions for carriage – Loading and unloading (RID) : CW13, CW28, CW31 Hazard identification number (RID) : 66 |
|
14.7. Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code |
|
| Not applicable | |
SECTION 15: Regulatory information |
|---|
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture |
| 15.1.1 EU-Regulations : |
| No REACH Annex XVII restrictions Actidione 98% AR is not on the REACH Candidate List Actidione 98% AR is not on the REACH Annex XIV List |
| 15.1.2. National regulations |
| Germany |
| AwSV/VwVwS Annex reference : Water hazard class (WGK) 3, strongly hazardous to water (Classification according to VwVwS, Annex 2; WGK No 890) 12th Ordinance Implementing the Federal Immission Control Act - 12.BImSchV : Is not subject of the 12. BlmSchV (Hazardous Incident Ordinance) |
| Denmark |
| Recommendations Danish Regulation : Young people below the age of 18 years are not allowed to use the product Pregnant/breastfeeding women working with the product must not be in direct contact with the product The requirements from the Danish Working Environment Authorities regarding work with carcinogens must be followed during use and disposal |
15.2 Chemical Safety Assessment |
| No additional information available |
SECTION 16: Other Information |
|---|